Microbial engineering for the production of advanced biofuels | Zendy

Pamela PeraltaYahya | Zendy; Fuzhong Zhang | Zendy; Stephen B. del Cardayré | Zendy; Jay D. Keasling | Zendy

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Microbial engineering for the production of advanced biofuels

Author(s) -

Pamela PeraltaYahya,

Fuzhong Zhang,

Stephen B. del Cardayré,

Jay D. Keasling

Publication year - 2012

Publication title -

nature

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 15.993

H-Index - 1226

eISSN - 1476-4687

pISSN - 0028-0836

DOI - 10.1038/nature11478

Subject(s) - biofuel , commercialization , biochemical engineering , raw material , synthetic biology , production (economics) , metabolic engineering , microbiology and biotechnology , aviation biofuel , fossil fuel , environmental science , bioenergy , business , engineering , chemistry , waste management , biology , ecology , economics , computational biology , biochemistry , macroeconomics , marketing , enzyme

Advanced biofuels produced by microorganisms have similar properties to petroleum-based fuels, and can 'drop in' to the existing transportation infrastructure. However, producing these biofuels in yields high enough to be useful requires the engineering of the microorganism's metabolism. Such engineering is not based on just one specific feedstock or host organism. Data-driven and synthetic-biology approaches can be used to optimize both the host and pathways to maximize fuel production. Despite some success, challenges still need to be met to move advanced biofuels towards commercialization, and to compete with more conventional fuels.

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