Open AccessThe Edinburgh human metabolic network reconstruction and its functional analysis
Author(s) -
Ma Hongwu,
Sorokin Anatoly,
Mazein Alexander,
Selkov Alex,
Selkov Evgeni,
Demin Oleg,
Goryanin Igor
Publication year - 2007
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1038/msb4100177
Subject(s) - biology , computational biology , metabolic network
A better understanding of human metabolism and its relationship with diseases is an important task in human systems biology studies. In this paper, we present a high‐quality human metabolic network manually reconstructed by integrating genome annotation information from different databases and metabolic reaction information from literature. The network contains nearly 3000 metabolic reactions, which were reorganized into about 70 human‐specific metabolic pathways according to their functional relationships. By analysis of the functional connectivity of the metabolites in the network, the bow‐tie structure, which was found previously by structure analysis, is reconfirmed. Furthermore, the distribution of the disease related genes in the network suggests that the IN (substrates) subset of the bow‐tie structure has more flexibility than other parts.