Open AccessThe interactome of human EGF/ErbB receptors
Author(s) -
Uetz Peter,
Stagljar Igor
Publication year - 2006
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1038/msb4100048
Subject(s) - biology , interactome , erbb , receptor , computational biology , microbiology and biotechnology , genetics , gene
When you search PubMed for'EGF receptor'(EGFR), the database returns more than 5000 hits. This is not entirely surprising given the receptor's eminent role in cancer biology. However, it is truly surprising that two recent papers published by the groups of Gavin MacBeath and Matthias Mann add a whole new dimension to the problem of EGFR signaling. They do that by using protein microarray and quantitative proteomics technologies to comprehensively and quantita-tively identify proteins associated with the cytosolic domains of the human EGFR family (Jones et al, 2005; Schulze et al, 2005).