Open AccessA comprehensive pathway map of epidermal growth factor receptor signaling
Author(s) -
Oda Kanae,
Matsuoka Yukiko,
Funahashi Akira,
Kitano Hiroaki
Publication year - 2005
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1038/msb4100014
Subject(s) - sbml , biology , systems biology , signal transduction , epidermal growth factor receptor , markup language , computational biology , cell signaling , microbiology and biotechnology , receptor , computer science , genetics , world wide web , xml
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best‐investigated signaling systems, both experimentally and computationally, and several computational models have been developed for dynamic analysis. A map of molecular interactions of the EGFR signaling system is a valuable resource for research in this area. In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow‐tie (or hourglass) structure with several feedback loops. The map is created using CellDesigner software that enables us to graphically represent interactions using a well‐defined and consistent graphical notation, and to store it in Systems Biology Markup Language (SBML).