Open Accessd N / d S does not show positive selection drives separation of polar‐tropical SAR11 populations
Author(s) -
Luo Haiwei,
Hughes Austin L
Publication year - 2012
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1038/msb.2012.58
Subject(s) - biology , selection (genetic algorithm) , separation (statistics) , polar , genetics , computational biology , statistics , physics , artificial intelligence , computer science , mathematics , astronomy
dN /dS does not show positive selection drives separation of polar-tropical SAR11 populations Molecular Systems Biology 8: 625 published online 20 November 2012; doi:10.1038/msb.2012.58 Large-scale sequencing of environmental microorganisms (including genomes, metagenomes, and metatranscriptomes) now allows researchers to apply sequence-based evolutionary genetics approaches to microbial ecology questions, including studying how microbes adapt to a diversity of natural environments. There is, however, a danger for misapplication and misinterpretation if the caveats and limitations of these evolutionary methods are not fully appreciated. Here, we highlight an example of such problems in an evolutionary analysis of potential positive selection within strains of SAR11 marine bacteria (Brown et al, 2012). We feel that these issues deserve wider recognition, particularly as evolutionar