Open AccessA human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
Author(s) -
Lefebvre Celine,
Rajbhandari Presha,
Alvarez Mariano J,
Bandaru Pradeep,
Lim Wei Keat,
Sato Mai,
Wang Kai,
Sumazin Pavel,
Kustagi Manjunath,
Bisikirska Brygida C,
Basso Katia,
Beltrao Pedro,
Krogan Nevan,
Gautier Jean,
DallaFavera Riccardo,
Califano Andrea
Publication year - 2010
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1038/msb.2010.31
Subject(s) - interactome , biology , foxm1 , mitosis , transcription factor , microbiology and biotechnology , dna replication factor cdt1 , cell cycle , gene , transcription (linguistics) , dna replication , computational biology , gene regulatory network , germinal center , genetics , gene expression , control of chromosome duplication , b cell , linguistics , philosophy , antibody
Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre‐replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues.