Open AccessmRNA turnover rate limits siRNA and microRNA efficacy
Author(s) -
Larsson Erik,
Sander Chris,
Marks Debora
Publication year - 2010
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1038/msb.2010.113
Subject(s) - biology , microrna , rna interference , messenger rna , computational biology , microbiology and biotechnology , rna , genetics , gene
Erik Larsson*, Chris Sander and Debora Marks* 1 Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA and 2 Department of Systems Biology, Harvard Medical School, Boston, MA, USA * Corresponding authors. D Marks, Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Alpert 536, Boston, MA 02115, USA. Tel.: þ 1 617 953 4107; Fax: þ 1 646 422 0717; E-mail: deboramarks@gmail.com or E Larsson, Computational Biology Center, Memorial Sloan–Kettering Cancer Center, New York, NY 10065, USA. Tel.: þ 1 646 888 2610; Fax: þ 1 212 422 0717; E-mail: larsson@cbio.mskcc.org