Open AccessApplications of genome‐scale metabolic reconstructions
Author(s) -
Oberhardt Matthew A,
Palsson Bernhard Ø,
Papin Jason A
Publication year - 2009
Publication title -
molecular systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.523
H-Index - 148
ISSN - 1744-4292
DOI - 10.1038/msb.2009.77
Subject(s) - biology , genome , computational biology , scale (ratio) , contextualization , variety (cybernetics) , genomics , systems biology , data science , field (mathematics) , evolutionary biology , genetics , computer science , artificial intelligence , gene , mathematics , pure mathematics , interpretation (philosophy) , programming language , physics , quantum mechanics
The availability and utility of genome‐scale metabolic reconstructions have exploded since the first genome‐scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high‐throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis‐driven discovery, (4) interrogation of multi‐species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome‐scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.