Open AccessThe vascular secret of Klotho
Author(s) -
Ewa Lewin,
Klaus Ølgaard
Publication year - 2015
Publication title -
kidney international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.499
H-Index - 276
eISSN - 1523-1755
pISSN - 0085-2538
DOI - 10.1038/ki.2015.80
Subject(s) - klotho , calcification , longevity , vascular smooth muscle , biology , medicine , endocrinology , kidney , genetics , smooth muscle
Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed in the vasculature or whether its vascular effects arise uniquely from its presence in the circulation.
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