Urea and protein carbamylation in ESRD: surrogate markers or partners in crime? | Zendy

Manuel T. Velasquez | Zendy; Ali Ramezani | Zendy; Dominic S. Raj | Zendy

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Urea and protein carbamylation in ESRD: surrogate markers or partners in crime?

Author(s) -

Manuel T. Velasquez,

Ali Ramezani,

Dominic S. Raj

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2015.78

Subject(s) - uremia , urea , toxicity , kidney disease , medicine , end stage renal disease , uremic toxins , mechanism (biology) , disease , chemistry , endocrinology , biochemistry , philosophy , epistemology

Protein carbamylation may result from chronic exposure to elevated levels of urea in patients with chronic kidney disease. Carbamylation could cause conformational changes in proteins resulting in alterations in binding sites and disturbances in cellular functions. Elevated levels of carbamylated protein have been shown to be associated with increased risk of death from cardiac causes in patients with end-stage renal disease. The precise mechanism by which carbamylated proteins mediate toxicity in uremia needs further investigation.

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