Uromodulin, kidney function, cardiovascular disease, and mortality | Zendy

Olivier Devuyst | Zendy; Murielle Bochud | Zendy

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Uromodulin, kidney function, cardiovascular disease, and mortality

Author(s) -

Olivier Devuyst,

Murielle Bochud

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2015.267

Subject(s) - tamm–horsfall protein , renal function , medicine , disease , kidney , kidney disease , physiology , pathology

Uromodulin (Tamm-Horsfall protein) is exclusively produced by the kidney and is the most abundant protein excreted in normal urine. The level of uromodulin in urine could represent a useful biomarker for renal tubular function. The study of Garimella et al. adds elements into the debate, by suggesting that, in elderly adults, low urinary uromodulin concentrations in spot urine identify people at risk of progressive kidney disease and mortality above and beyond established markers of kidney disease.

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