What is myeloperoxidase doing in ANCA-associated glomerulonephritis? | Zendy

William G. Couser | Zendy; Richard J. Johnson | Zendy

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What is myeloperoxidase doing in ANCA-associated glomerulonephritis?

Author(s) -

William G. Couser,

Richard J. Johnson

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2015.259

Subject(s) - myeloperoxidase , glomerulonephritis , anti neutrophil cytoplasmic antibody , immunology , antibody , vasculitis , antigen , medicine , disease , pathology , inflammation , kidney

O'Sullivan et al. describe glomerular localization of myeloperoxidase (MPO) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and correlate the amount of deposition with severity of injury. MPO is the antigen against which anti-MPO ANCAs are directed, the antigen to which pathogenic T cells that can induce antibody-independent AAV are directed, and MPO can induce glomerular injury directly by interacting with H2O2 and a halide to halogenate glomerular structures. All three of these roles are likely involved in human disease.

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