Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy | Zendy

Lin Sun | Zendy; Yashpal S. Kanwar | Zendy

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Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy

Author(s) -

Lin Sun,

Yashpal S. Kanwar

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2015.250

Subject(s) - diabetic nephropathy , medicine , tumor necrosis factor alpha , proinflammatory cytokine , context (archaeology) , nephropathy , inflammation , relevance (law) , immunology , diabetes mellitus , endocrinology , biology , paleontology , political science , law

An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical microinflammation with influx of macrophages and consequent generation of myriad proinflammatory cytokines and ensuing kidney damage. Among various proinflammatory cytokines, tumor necrosis factor-α (TNF-α) has attracted the most attention, since it amplifies the inflammatory network of cytokines, leading to worsening of the progression of diabetic nephropathy. The article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.

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