Epigenetic regulation in acute kidney injury: new light in a dark area | Zendy

Chengyuan Tang | Zendy; Zheng Dong | Zendy

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Epigenetic regulation in acute kidney injury: new light in a dark area

Author(s) -

Chengyuan Tang,

Zheng Dong

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2015.229

Subject(s) - epigenetics , acute kidney injury , histone , acetylation , kidney , pathogenesis , methylation , medicine , dna methylation , bioinformatics , biology , cancer research , gene , genetics , pathology , gene expression

Epigenetic mechanisms have been implicated in the pathogenesis of renal diseases, including acute kidney injury (AKI). Mar et al. now unravel the acetylation and methylation at histones that are associated with the transcription of key genes in AKI. Notably, histone modifications display a remarkable heterogeneity in ischemic and endotoxic AKI. Targeting epigenetic programs may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery.

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