Epigenetic control of podocyte differentiation: a new target of the renin–angiotensin system in kidney disease | Zendy

Denis Féliers | Zendy

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Epigenetic control of podocyte differentiation: a new target of the renin–angiotensin system in kidney disease

Author(s) -

Denis Féliers

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2015.224

Subject(s) - podocyte , renin–angiotensin system , epigenetics , kidney disease , angiotensin ii , kidney glomerulus , kidney , disease , medicine , biology , bioinformatics , endocrinology , glomerulonephritis , genetics , gene , proteinuria , receptor , blood pressure

Glomerular podocyte integrity is essential to limit protein filtration in the urine. Hayashi et al. report that epigenetic mechanisms control podocyte differentiation and that activation of the renin-angiotensin system in kidney disease affects podocyte differentiation and proteinuria by resetting the podocyte epigenome. These findings suggest that modulation of DNA methylation could be a promising target for the control of proteinuric kidney disease.

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