The battlefield at arteriovenous crossroads: invading arterial smooth muscle cells occupy the outflow tract of fistulas | Zendy

Jan Rotmans | Zendy; Taisiya Bezhaeva | Zendy

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The battlefield at arteriovenous crossroads: invading arterial smooth muscle cells occupy the outflow tract of fistulas

Author(s) -

Jan Rotmans,

Taisiya Bezhaeva

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2015.124

Subject(s) - medicine , vascular smooth muscle , intimal hyperplasia , smooth muscle , battlefield , anatomy , hyperplasia , artery , neointimal hyperplasia , arteriovenous fistula , myofibroblast , cardiology , surgery , restenosis , ancient history , stent , history , fibrosis

There is an ongoing debate about the anatomical origin of the neointimal cells that are responsible for venous stenotic lesions in arteriovenous fistulas. Liang and co-workers show that vascular smooth muscle cells from the feeding artery contribute substantially to venous intimal hyperplasia in a murine AVF model. In addition, they show that increased Notch signaling is the driving force behind FSP-1-mediated migration of these cells to the venous outflow tract.

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