Cyclical dehydration-induced renal injury and Mesoamerican nephropathy: as sweet by any other name? | Zendy

R. Brooks Robey | Zendy

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Cyclical dehydration-induced renal injury and Mesoamerican nephropathy: as sweet by any other name?

Author(s) -

R. Brooks Robey

Publication year - 2014

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2014.47

Subject(s) - dehydration , renal injury , nephropathy , medicine , acute kidney injury , renal mass , urology , chemistry , kidney , endocrinology , biochemistry , nephrectomy , diabetes mellitus

Severe cyclical dehydration induces chronic renal injury in rodents. This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity.

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