Dendritic cells and innate immunity in kidney transplantation | Zendy

Quan Zhuang | Zendy; Fadi G. Lakkis | Zendy

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Dendritic cells and innate immunity in kidney transplantation

Author(s) -

Quan Zhuang,

Fadi G. Lakkis

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2014.430

Subject(s) - allorecognition , innate immune system , immunology , transplantation , monocyte , acquired immune system , medicine , kidney , biology , immunosuppression , immune system , t cell

This review summarizes emerging concepts related to the roles of dendritic cells (DCs) and innate immunity in organ transplant rejection. First, it highlights the primary role that recipient, rather than donor, DCs have in rejection and reviews their origin and function in the transplanted kidney. Second, it introduces the novel concept that recognition of allogeneic non-self by host monocytes (referred to here as innate allorecognition) is necessary for initiating rejection by inducing monocyte differentiation into mature, antigen-presenting DCs. Both concepts provide opportunities for preventing rejection by targeting monocytes or DCs.

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