The impact of cold ischemia time on renal transplant outcome | Zendy

Claudio Ponticelli | Zendy

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The impact of cold ischemia time on renal transplant outcome

Author(s) -

Claudio Ponticelli

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2014.359

Subject(s) - ischemia , medicine , transplantation , cold storage , hypoxia (environmental) , adenosine triphosphate , lactic acidosis , pharmacology , chemistry , biology , oxygen , organic chemistry , horticulture

Cold ischemia triggers a cascade of noxious effects, which are amplified by restoration of blood supply reperfusion. These injuries generate inflammatory and immune responses that may potentially result in delayed graft function, enhanced alloimmune reactivity, and development of progressive pathological changes. Debout et al. outline the clinical importance of cold ischemia time in renal transplantation by demonstrating that each additional hour of cold ischemia can increase the risk of allograft failure and death.

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