If you lose your nerves, at least you will not get kidney fibrosis! | Zendy

Peter Boor | Zendy; Marios Papasotiriou | Zendy

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If you lose your nerves, at least you will not get kidney fibrosis!

Author(s) -

Peter Boor,

Marios Papasotiriou

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2014.327

Subject(s) - calcitonin gene related peptide , efferent , medicine , receptor , fibrosis , nephrology , kidney , calcitonin , afferent , endocrinology , norepinephrine , neuroscience , neuropeptide , biology , dopamine

Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fibers are involved via norepinephrine and α2-adrenergic receptors as well as calcitonin gene-related peptide (CGRP) and its receptors.

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