Open AccessImmunity unmasks APOL1 in collapsing glomerulopathy
Author(s) -
Bairbre McNicholas,
Peter J. Nelson
Publication year - 2015
Publication title -
kidney international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.499
H-Index - 276
eISSN - 1523-1755
pISSN - 0085-2538
DOI - 10.1038/ki.2014.325
Subject(s) - immunity , medicine , glomerulopathy , immunology , glomerulonephritis , kidney , immune system
Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.
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