Urea for hyponatremia? | Zendy

Richard H. Sterns | Zendy; Stephen M. Silver | Zendy; John K. Hix | Zendy

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Urea for hyponatremia?

Author(s) -

Richard H. Sterns,

Stephen M. Silver,

John K. Hix

Publication year - 2015

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2014.320

Subject(s) - medicine , hyponatremia , vasopressin antagonists , intracranial pressure , intensive care medicine , cerebral edema , vasopressin , antidiuretic , clinical trial , anesthesia , receptor , antagonist

Once the standard of care for cerebral edema, urea can also be used to treat hyponatremia. The 2014 European Clinical Practice Guidelines recommend urea for the treatment of the syndrome of inappropriate antidiuretic hormone, while discouraging use of vasopressin antagonists. Although there is evidence that urea can diminish hypertonic injury to brain cells caused by rapid correction of hyponatremia, clinical trials are needed that include patients at high risk to develop complications from overcorrection.

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