Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation? | Zendy

Clare L. Hawkins | Zendy

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Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

Author(s) -

Clare L. Hawkins

Publication year - 2014

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2014.256

Subject(s) - uremia , cyanate , kidney disease , uremic toxins , chemistry , in vivo , medicine , endocrinology , biochemistry , biology , polymer chemistry , microbiology and biotechnology

Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.

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