Complement activation in the tubulointerstitium: AKI, CKD, and in between | Zendy

J. Brar | Zendy; Richard J. Quigg | Zendy

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Complement activation in the tubulointerstitium: AKI, CKD, and in between

Author(s) -

J. Brar,

Richard J. Quigg

Publication year - 2014

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2014.168

Subject(s) - complement (music) , complement system , medicine , intensive care medicine , immunology , chemistry , antibody , biochemistry , complementation , gene , phenotype

Complement activation is actively regulated to prevent injudicious activation, such as on peritubular endothelia and basolateral aspects of tubules. Miao et al. studied mice in which the key complement regulator, Crry, was deleted from tubular cells. This lacked functional consequence in unmanipulated animals. Yet, following ischemia-reperfusion, there was greater injury due to alternative pathway activation of C5. When the balance between complement activation and regulation is tipped towards the former, pathologic complement activation can ensue.

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