The heterogeneous mononuclear phagocyte system of the kidney | Zendy

Kevin Woollard | Zendy; Charles D. Pusey | Zendy

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The heterogeneous mononuclear phagocyte system of the kidney

Author(s) -

Kevin Woollard,

Charles D. Pusey

Publication year - 2014

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2013.448

Subject(s) - mononuclear phagocyte system , phagocyte , peripheral blood mononuclear cell , immunology , kidney , glomerulonephritis , cd11c , kidney disease , cd8 , population , medicine , biology , pathology , antigen , immune system , phenotype , biochemistry , environmental health , gene , in vitro

The kidney has a diverse repertoire of cells that make up the mononuclear phagocyte system (MPS). Wu et al. identify a population of CD8αα+CD11c+MHC-II+ blood precursors that display dendritic cell-like characteristics in the glomeruli. These cells show increased recruitment in a rat anti-glomerular basement membrane glomerulonephritis model and were able to attenuate disease. This study highlights the importance of the MPS in kidney disease and the need to better understand it to develop immunotherapeutics translatable to the renal patient.

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