Has the circulating permeability factor in primary FSGS been found? | Zendy

J. Ashley Jefferson | Zendy; Stuart J. Shankland | Zendy

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Has the circulating permeability factor in primary FSGS been found?

Author(s) -

J. Ashley Jefferson,

Stuart J. Shankland

Publication year - 2013

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2013.204

Subject(s) - supar , focal segmental glomerulosclerosis , medicine , nephrotic syndrome , podocyte , glomerulosclerosis , pathogenesis , urokinase receptor , proteinuria , pathology , immunology , plasminogen activator , endocrinology , kidney

A circulating permeability factor has long been implicated in the pathogenesis of primary focal segmental glomerulosclerosis (FSGS). Evidence in animal models and now in several cohorts of patients with primary FSGS suggests a role for the soluble urokinase-type plasminogen activator receptor (suPAR) as a biomarker and perhaps as a contributing factor. Confirmation of these findings might lead to new diagnostic and therapeutic strategies for FSGS as well as a better understanding of podocyte dysfunction.

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