Biomarkers and creatinine in AKI: the trough of disillusionment or the slope of enlightenment? | Zendy

Zoltán Endre | Zendy; John W. Pickering | Zendy

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Biomarkers and creatinine in AKI: the trough of disillusionment or the slope of enlightenment?

Author(s) -

Zoltán Endre,

John W. Pickering

Publication year - 2013

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2013.168

Subject(s) - creatinine , medicine , intensive care medicine , acute kidney injury , intensive care unit , enlightenment , sampling (signal processing) , computer science , epistemology , philosophy , filter (signal processing) , computer vision

Assessment of acute kidney biomarkers against changes in plasma creatinine is beset by issues of heterogeneity of study cohorts and timing of sampling. Siew and colleagues attempt to minimize these issues in a case-control study of three biomarkers in the intensive care unit. The results highlight the inherent methodological difficulties and the need to reference structural injury biomarkers against more meaningful outcomes.

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