Hypertension-misattributed kidney disease in African Americans | Zendy

Karl Skorecki | Zendy; Walter G. Wasser | Zendy

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Hypertension-misattributed kidney disease in African Americans

Author(s) -

Karl Skorecki,

Walter G. Wasser

Publication year - 2012

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2012.369

Subject(s) - medicine , kidney disease , disease , intensive care medicine

Lipkowitz et al. extend the African American Study of Kidney Disease and Hypertension to the level of genetic epidemiology, in a case-control study design. Analysis of genotypes at the APOL1 kidney disease risk region supports a paradigm shift in which genetic risk is proximate to both kidney disease and hypertension. The findings mandate urgency in clarifying mechanisms whereby APOL1 region risk variants interact with environmental triggers to cause progressive kidney disease accompanied by dangerous hypertension.

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