Strategies to reverse endothelial dysfunction in diabetic nephropathy | Zendy

Shawn S. Badal | Zendy; Farhad R. Danesh | Zendy

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Strategies to reverse endothelial dysfunction in diabetic nephropathy

Author(s) -

Shawn S. Badal,

Farhad R. Danesh

Publication year - 2012

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2012.306

Subject(s) - enos , endothelial dysfunction , nitric oxide , medicine , diabetes mellitus , endothelial nitric oxide synthase , diabetic nephropathy , nephropathy , nitric oxide synthase type iii , pathophysiology , endothelium , nitric oxide synthase , endocrinology

Endothelial dysfunction underlies the basic pathophysiology of microvascular complications of diabetes. Endothelial dysfunction is associated with impaired nitric oxide (NO) availability. Since NO production is tightly regulated by endothelial nitric oxide synthase (eNOS), several therapeutic strategies have been investigated and proposed to improve eNOS bioavailability in the vasculature. The findings of Cheng et al. suggest that increased availability of eNOS may be an effective strategy in restoring endothelial function in patients with diabetic nephropathy.

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