Intracellular cAMP signaling by soluble adenylyl cyclase | Zendy

Martín Tresguerres | Zendy; Lonny R. Levin | Zendy; Jochen Buck | Zendy

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Intracellular cAMP signaling by soluble adenylyl cyclase

Author(s) -

Martín Tresguerres,

Lonny R. Levin,

Jochen Buck

Publication year - 2011

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2011.95

Subject(s) - adenylyl cyclase , adcy10 , second messenger system , adcy9 , cyclic adenosine monophosphate , intracellular , adcy6 , camp dependent pathway , cytoplasm , microbiology and biotechnology , adcy3 , signal transduction , chemistry , adenosine , biochemistry , biology , receptor

Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is distinct from the more widely studied source of cAMP, the transmembrane adenylyl cyclases (tmACs); its activity is uniquely regulated by bicarbonate anions, and it is distributed throughout the cytoplasm and in cellular organelles. Due to its unique localization and regulation, sAC has various functions in a variety of physiological systems that are distinct from tmACs. In this review, we detail the known functions of sAC, and we reassess commonly held views of cAMP signaling inside cells.

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