The biology of immunoglobulin free light chains and kidney injury | Zendy

Kolitha Basnayake | Zendy; Stephanie Stringer | Zendy; Colin A. Hutchison | Zendy; Paul Cockwell | Zendy

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The biology of immunoglobulin free light chains and kidney injury

Author(s) -

Kolitha Basnayake,

Stephanie Stringer,

Colin A. Hutchison,

Paul Cockwell

Publication year - 2011

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2011.94

Subject(s) - immunoglobulin light chain , kidney , antibody , cell injury , medicine , acute kidney injury , immunoglobulin g , pathology , dyscrasia , kidney disease , plasma cell , immunology , biology , biochemistry , apoptosis

Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.

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