WNT/β-catenin signaling in polycystic kidney disease | Zendy

Anne Wuebken | Zendy; Kai M. SchmidtOtt | Zendy

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WNT/β-catenin signaling in polycystic kidney disease

Author(s) -

Anne Wuebken,

Kai M. SchmidtOtt

Publication year - 2011

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2011.87

Subject(s) - wnt signaling pathway , polycystic kidney disease , cystic kidney disease , cyst , lrp5 , disease , kidney , signal transduction , biology , catenin , beta catenin , lrp6 , microbiology and biotechnology , cancer research , medicine , pathology , endocrinology

Cystic kidney diseases have been linked to defective WNT signal transduction. Perturbations of cystic disease genes cause activation of canonical WNT/β-catenin/TCF/Lef1 signaling in model organisms and cultured cells. Inappropriate levels of WNT/β-catenin signaling cause renal cyst formation in mice. These observations have prompted the idea that an activation of WNT/β-catenin signaling may constitute a common causative event in cyst formation. Now this view is challenged by key genetic mouse models of cystic kidney disease that do not display WNT/β-catenin activity in cyst-lining epithelia.

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