Open Access20-HETE in acute kidney injury
Author(s) -
Richard J. Roman,
Talha Akbulut,
Frank Park,
Kevin R. Regner
Publication year - 2010
Publication title -
kidney international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.499
H-Index - 276
eISSN - 1523-1755
pISSN - 0085-2538
DOI - 10.1038/ki.2010.396
Subject(s) - acute kidney injury , medicine , intensive care medicine , ischemia , kidney , pharmacology
Ischemia/reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) that is associated with a patient mortality of up to 50%. Currently there are not effective pharmacologic therapies for AKI. This Commentary highlights recent evidence indicating that 20-HETE plays an important role in IRI and that drugs that target this pathway have potential as therapeutic agents for AKI.
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