JAK/STAT signaling in renal diseases | Zendy

Peter Y. Chuang | Zendy; John Cijiang He | Zendy

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JAK/STAT signaling in renal diseases

Author(s) -

Peter Y. Chuang,

John Cijiang He

Publication year - 2010

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2010.158

Subject(s) - stat , jak stat signaling pathway , janus kinase , janus kinase 2 , stat3 , signal transduction , cancer research , medicine , janus kinase 1 , socs3 , stat4 , cytokine , stat protein , microbiology and biotechnology , biology , receptor tyrosine kinase

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling. Signaling through the JAK/STAT pathway is important for the kidney's response to injury in disease. Pang et al. confirm that activation of STAT3 mediates renal fibrosis in the unilateral ureteral obstruction experimental model.

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