T cells and dendritic cells in glomerular disease: the new glomerulotubular feedback loop
Author(s) -
SunSang J. Sung,
W. Kline Bolton
Publication year - 2009
Publication title -
kidney international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.499
H-Index - 276
eISSN - 1523-1755
pISSN - 0085-2538
DOI - 10.1038/ki.2009.489
Subject(s) - kidney disease , proteinuria , nephritis , loop (graph theory) , glomerulonephritis , immunology , medicine , kidney , endocrinology , urology , chemistry , mathematics , combinatorics
A newly described glomerulotubular feedback loop may explain the relationship between glomerular damage, epitope spreading, tubulointerstitial nephritis, proteinuria as a progression factor, and the importance of the local milieu in kidney damage. It also opens the horizons for exciting innovative approaches to therapy of both acute and chronic kidney diseases.
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