The enigmatic parietal epithelial cell is finally getting noticed: a review | Zendy

Takamoto Ohse | Zendy; Jeffrey W. Pippin | Zendy; Alice M. Chang | Zendy; Ronald D. Krofft | Zendy; Jeffrey H. Miner | Zendy; Michael R. Vaughan | Zendy; Stuart J. Shankland | Zendy

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The enigmatic parietal epithelial cell is finally getting noticed: a review

Author(s) -

Takamoto Ohse,

Jeffrey W. Pippin,

Alice M. Chang,

Ronald D. Krofft,

Jeffrey H. Miner,

Michael R. Vaughan,

Stuart J. Shankland

Publication year - 2009

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2009.386

Subject(s) - glomerulus , disease , cell type , function (biology) , epithelium , biology , kidney glomerulus , pathology , cell , microbiology and biotechnology , neuroscience , medicine , glomerulonephritis , kidney , endocrinology , genetics

Although the normal glomerulus comprises four resident cell types, least is known about the parietal epithelial cells (PECs). This comprehensive review addresses the cellular origin of PECs, discusses the normal structure and protein makeup of PECs, describes PEC function, and defines the responses to injury in disease and how these events lead to clinical events. The data show that PECs have unique properties and that new functions are being recognized such as their role in differentiating into podocytes during disease.

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