Renal function and genetic variation in dopamine D1 receptor: is the case strong enough? | Zendy

Krzysztof Kiryluk | Zendy

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Renal function and genetic variation in dopamine D1 receptor: is the case strong enough?

Author(s) -

Krzysztof Kiryluk

Publication year - 2009

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2009.328

Subject(s) - gene , dopamine receptor , renal function , dopaminergic , blood pressure , dopamine , genetics , genetic variation , receptor , biology , genetic association , medicine , endocrinology , single nucleotide polymorphism , genotype

Polymorphisms in the genes involved in the dopaminergic system have been implicated in susceptibility to hypertension. A new study by Fung et al. takes a closer look at the association of genetic variants in the dopamine D(1) receptor gene (DRD1) with blood pressure and renal parameters. Although the study does not confirm an association with blood pressure, it suggests a new link between a common variant in the 5'-untranslated region of the DRD1 gene and low glomerular filtration rate.

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