Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification? | Zendy

Thilo Krueger | Zendy; Ralf Westenfeld | Zendy; Markus Ketteler | Zendy; Leon J. Schurgers | Zendy; Jürgen Floege | Zendy

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Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?

Author(s) -

Thilo Krueger,

Ralf Westenfeld,

Markus Ketteler,

Leon J. Schurgers,

Jürgen Floege

Publication year - 2009

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2009.126

Subject(s) - medicine , risk factor , vitamin , calcification , vitamin d deficiency , vitamin d and neurology , kidney disease

The purpose of this review is to summarize currently available evidence implicating vitamin K in the pathogenesis of vascular calcification (VC), in particular arterial medial calcification. In doing so, we try to provide a rationale for an interventional clinical study testing whether vitamin K supplementation can retard VC or even affect cardiovascular mortality in chronic kidney disease patients. Additionally, we wish to give an overview of the current literature indicating potential adverse effects of long-term vitamin K antagonists in this population.

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