Hyperphosphatemia of chronic kidney disease | Zendy

Keith A. Hruska | Zendy; Suresh Mathew | Zendy; Richard Lund | Zendy; Ping Qiu | Zendy; Raymond D. Pratt | Zendy

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Hyperphosphatemia of chronic kidney disease

Author(s) -

Keith A. Hruska,

Suresh Mathew,

Richard Lund,

Ping Qiu,

Raymond D. Pratt

Publication year - 2008

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2008.130

Subject(s) - hyperphosphatemia , kidney disease , medicine , kidney , sevelamer , pathology

Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the mechanisms by which hyperphosphatemia acts on neointimal vascular cells that are stimulated to mineralize in chronic kidney disease. The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented.

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