Proteinuria in diabetic kidney disease: A mechanistic viewpoint | Zendy

J. Ashley Jefferson | Zendy; Stuart J. Shankland | Zendy; Raimund Pichler | Zendy

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Proteinuria in diabetic kidney disease: A mechanistic viewpoint

Author(s) -

J. Ashley Jefferson,

Stuart J. Shankland,

Raimund Pichler

Publication year - 2008

Publication title -

kidney international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.499

H-Index - 276

eISSN - 1523-1755

pISSN - 0085-2538

DOI - 10.1038/ki.2008.128

Subject(s) - proteinuria , kidney disease , medicine , diabetes mellitus , disease , kidney , intensive care medicine , endocrinology

Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk factor for both renal disease progression, and cardiovascular disease. Although the characteristic pathological changes in DKD include thickening of the glomerular basement membrane and mesangial expansion, these changes per se do not readily explain how patients develop proteinuria. Recent advances in podocyte and glomerular endothelial cell biology have shifted our focus to also include these cells of the glomerular filtration barrier in the development of proteinuria in DKD. This review describes the pathophysiological mechanisms at a cellular level which explain why patients with DKD develop proteinuria.

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