Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice | Zendy

Julien Santo | Zendy; Celia LopezHerrera | Zendy; Cécile Apolit | Zendy; Yacine Barèche | Zendy; Laure Lapasset | Zendy; Carine Chavey | Zendy; Serena Capozi | Zendy; Florence MahuteauBetzer | Zendy; Romain Najman | Zendy; Pauline Fornarelli | Zendy; Isabel C. LópezMejía | Zendy; Guillaume E. Béranger | Zendy; François Casas | Zendy; EzZoubir Amri | Zendy; Bernard Pau | Zendy; Didier Scherrer | Zendy; Jamal Tazi | Zendy

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Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice

Author(s) -

Julien Santo,

Celia LopezHerrera,

Cécile Apolit,

Yacine Barèche,

Laure Lapasset,

Carine Chavey,

Serena Capozi,

Florence MahuteauBetzer,

Romain Najman,

Pauline Fornarelli,

Isabel C. LópezMejía,

Guillaume E. Béranger,

François Casas,

EzZoubir Amri,

Bernard Pau,

Didier Scherrer,

Jamal Tazi

Publication year - 2016

Publication title -

international journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.663

H-Index - 225

eISSN - 1476-5497

pISSN - 0307-0565

DOI - 10.1038/ijo.2016.220

Subject(s) - white adipose tissue , rna splicing , adipose tissue , alternative splicing , lmna , endocrinology , gene isoform , medicine , energy homeostasis , knockout mouse , microbiology and biotechnology , biology , obesity , biochemistry , gene , lamin , rna , receptor

Bakground/Objectives:Intense drug discovery efforts in the metabolic field highlight the need for novel strategies for the treatment of obesity. Alternative splicing (AS) and/or polyadenylation enable the LMNA gene to express distinct protein isoforms that exert opposing effects on energy metabolism and lifespan. Here we aimed to use the splicing factor SRSF1 that contribute to the production of these different isoforms as a target to uncover new anti-obesity drug.

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