Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles | Zendy

Olivier Morel | Zendy; F. Luca | Zendy; L. Grunebaum | Zendy; Laurence Jesel | Zendy; Nicolás Meyer | Zendy; Dominique Desprez | Zendy; Stéphane Robert | Zendy; Françoise DignatGeorge | Zendy; Florence Toti | Zendy; Chantal Simon | Zendy; B. Goichot | Zendy

Open Access

Short-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles

Author(s) -

Olivier Morel,

F. Luca,

L. Grunebaum,

Laurence Jesel,

Nicolás Meyer,

Dominique Desprez,

Stéphane Robert,

Françoise DignatGeorge,

Florence Toti,

Chantal Simon,

B. Goichot

Publication year - 2011

Publication title -

international journal of obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.663

H-Index - 225

eISSN - 1476-5497

pISSN - 0307-0565

DOI - 10.1038/ijo.2011.19

Subject(s) - medicine , endocrinology , leptin , platelet , platelet activation , inflammation , very low calorie diet , endothelium , immunology , weight loss , obesity

In obesity, metabolic stress and inflammation in injured tissues could favour enhanced shedding of procoagulant microparticles (MPs). At sites of endothelium injury, the swift recruitment of procoagulant leukocyte-derived MPs enables the initiation of blood coagulation and thrombus growth.

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