Open AccessShort-term very low-calorie diet in obese females improves the haemostatic balance through the reduction of leptin levels, PAI-1 concentrations and a diminished release of platelet and leukocyte-derived microparticles
Author(s) -
Olivier Morel,
F. Luca,
Lélia Grunebaum,
Laurence Jesel,
Nicolás Meyer,
Dominique Desprez,
Stéphane Robert,
Françoise Dignat-George,
Florence Toti,
Chantal Simon,
B. Goichot
Publication year - 2011
Publication title -
international journal of obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.663
H-Index - 225
eISSN - 1476-5497
pISSN - 0307-0565
DOI - 10.1038/ijo.2011.19
Subject(s) - medicine , endocrinology , leptin , platelet , platelet activation , inflammation , very low calorie diet , endothelium , immunology , weight loss , obesity
In obesity, metabolic stress and inflammation in injured tissues could favour enhanced shedding of procoagulant microparticles (MPs). At sites of endothelium injury, the swift recruitment of procoagulant leukocyte-derived MPs enables the initiation of blood coagulation and thrombus growth.