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Macrophage polarization and function: new prospects for fibrotic disease
Author(s) -
Zhou Dexi,
Yang Kui,
Chen Lu,
Wang Yaqin,
Zhang Wen,
Xu Zhenyu,
Zuo Jian,
Jiang Hui,
Luan Jiajie
Publication year - 2017
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2017.64
Subject(s) - macrophage polarization , macrophage , function (biology) , disease , immunology , political science , medicine , biology , pathology , microbiology and biotechnology , genetics , in vitro
Fibrosis is commonly regarded as a pathological and dynamic process with the hallmarks of chronic inflammation and wound healing. Emerging evidence indicates that heterogeneous monocyte–macrophage lineage cells are indispensable for mounting either pro‐fibrotic or anti‐fibrotic responses in different stages during fibrotic pathogenesis. This review highlights the evolving roles of macrophage polarization and functions linked to fibrosis in multiple organs. In the future, identifying the molecular and cellular factors that influence the macrophage phenotypic balance may provide novel therapeutic approaches for fibrotic diseases.