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Influenza‐induced lung T rm : not all memories last forever
Author(s) -
Van BraeckelBudimir Natalija,
Harty John T
Publication year - 2017
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2017.32
Subject(s) - immunological memory , immunization , immunology , influenza a virus , immunity , virology , population , virus , lung , biology , medicine , immune system , environmental health
In the light of new findings that lung tissue resident memory CD8 + T cells (T rm ) represent major mediators of heterosubtypic immunity against influenza virus, it is of utmost importance to understand the basic biological mechanisms behind induction, formation and maintenance of this cell population. Addressing these important knowledge gaps will potentially inform development of superior, broadly protective influenza vaccines and new immunization strategies.