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IL‐10‐producing, ST2‐expressing Foxp3 + T cells in multiple sclerosis brain lesions
Author(s) -
Zandee Stephanie Elizabeth Johanna,
O'Connor Richard Anthony,
Mair Iris,
Leech Melanie Dawn,
Williams Anna,
Anderton Stephen Mark
Publication year - 2017
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2017.3
Subject(s) - multiple sclerosis , foxp3 , immunology , peripheral blood , inflammation , central nervous system , il 2 receptor , receptor , function (biology) , disease , medicine , biology , neuroscience , microbiology and biotechnology , pathology , immune system , t cell
CD4 + Foxp3 + T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro‐inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3 + cells in the brains of MS patients predominantly produce interleukin‐10 (IL‐10) and show high expression of the IL‐33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function.