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Mycobacterium tuberculosis infection of the ‘non‐classical immune cell’
Author(s) -
Randall Philippa J,
Hsu NaiJen,
Quesniaux Valerie,
Ryffel Bernhard,
Jacobs Muazzam
Publication year - 2015
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2015.43
Subject(s) - immune system , mycobacterium tuberculosis , biology , immunology , myeloid , cell , tuberculosis , microbiology and biotechnology , medicine , genetics , pathology
Mycobacterium tuberculosis can infect ‘non‐classical immune cells’, which comprise a significant constituency of cells that reside outside of those defined as ‘classical immune cells’ from myeloid or lymphoid origin. Here we address the influence of specific ‘non‐classical immune cells’ in host responses and their effects in controlling mycobacterial growth or enabling an environment conducive for bacilli persistence. The interaction of M. tuberculosis with epithelial cells, endothelial cells, fibroblasts, adipocytes, glia and neurons and downstream cellular responses that often dictate immune regulation and disease outcome are discussed. Functional integration and synergy between ‘classical’ and ‘non‐classical immune cells’ are highlighted as critical for determining optimal immune outcomes that favour the host.