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The functional contribution of calcium ion flux heterogeneity in T cells
Author(s) -
Christo Susan N,
Diener Kerrilyn R,
Hayball John D
Publication year - 2015
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2015.34
Subject(s) - calcium , flux (metallurgy) , ion , chemistry , biophysics , biology , organic chemistry
The role of intracellular calcium ion oscillations in T‐cell physiology is being increasingly appreciated by studies that describe how unique temporal and spatial calcium ion signatures can control different signalling pathways. Within this review, we provide detailed mechanisms of calcium ion oscillations, and emphasise the pivotal role that calcium signalling plays in directing crucial events pertaining to T‐cell functionality. We also describe methods of calcium ion quantification, and take the opportunity to discuss how a deeper understanding of calcium signalling combined with new detection and quantification methodologies can be used to better design immunotherapies targeting T‐cell responses.