Moving to the suburbs: T‐cell positioning within lymph nodes during activation and memory

Lymph nodes are highly organized secondary lymphoid structures crucial for the initiation of immune responses. Naive T cells are strategically located within lymph nodes to optimize their encounter with antigen‐loaded dendritic cells. Recent advances in 3D lymph node imaging and tissue reconstruction along with methods for the detection of chemokine expression and gradients have highlighted how T cells position themselves during activation and memory responses. This article covers new insights into the guidance mechanisms that co‐ordinate T‐cell responses within draining lymph nodes. Furthering our understanding of how these pathways are regulated and promoted will lead to the exploitation of T‐cell positioning to further strategize vaccine design.