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Chemokines in cellular positioning and human disease
Author(s) -
Groom Joanna R
Publication year - 2015
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2015.27
Subject(s) - chemokine , chemokine receptor , biology , effector , identification (biology) , disease , immunology , neuroscience , computational biology , microbiology and biotechnology , inflammation , medicine , pathology , botany
The April 2015 issue contains a Special Feature on “Chemokines in cellular positioning and human disease”. Chemokines serve as critical extracellular mediators of cell migration and retention. Recent studies have highlighted the importance of how cells are positioned within peripheral and lymphoid tissues for the development of timely effector and memory responses. In addition, advances in structural determination of chemokine receptor‐ligand complexes and the identification of genetic mutations that impact cell migration have brought us closer to targeting this system for the development of new anti‐inflammatory and anti‐tumor based drugs. Immunology and Cell Biology thanks the coordinator of this Special Feature ‐ Joanna Groom ‐ for her planning and input.