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The emerging role of mTOR signalling in antibacterial immunity
Author(s) -
AbdelNour Mena,
Tsalikis Jessica,
Kleinman David,
Girardin Stephen E
Publication year - 2014
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1038/icb.2014.3
Subject(s) - pi3k/akt/mtor pathway , autophagy , regulator , microbiology and biotechnology , rptor , signalling , biology , innate immune system , immunity , signal transduction , immune system , immunology , biochemistry , apoptosis , gene
Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll‐like receptor‐dependent innate responses and in the activation of T cells and antigen‐presenting cells. We also highlight the importance of amino‐acid starvation‐driven mTOR inhibition in the control of autophagy and intracellular bacterial clearance.